Research advances in the virulence factors of Klebsiella pneumoniae－A review

Abstract:

Abstract:Klebsiella pneumoniae is of great attractiveness because it naturally produces a series of bulk chemicals such as 1，3-propanediol，2，3-butanediol and 3-hydroxypropionic acid．Although this species has been fueled in recent years，its pathogenicity is considered an obstacle hindering industrial applications． Here we portray a picture of the virulence factors，including pili，receptors，capsular polysaccharides，lipopolysaccharides，and newly identified virulence factors．This review covers aspects of virulence genes，proteins，metabolic activities，as well as the mechanisms underlying infection and immune responses． Based on state-of-the-art advances in metabolic engineering and synthetic biology，the strategies for eliminating or attenuating the virulence of K． pneumoniae were proposed，and the feasibilities for these protocols were also briefly discussed.