Mics of the Clostridium thermocellum in lignocellulose degradation—A review

Abstract:

Abstract: Clostridium thermocellum (C.thermocellum ) is the dominant microorganism that can efficiently degrade lignocellulose． Extensive studies were done for secreting the cell surface-bound protein complex known as the cellulosome．C.thermocellum is regulated by carbon sources，reflected in overall multiple cellulase production and in the cellulosomal subunit profile．To produce a cellulosomal protein complex is a dynamic assembly process．In recent years，it becomes a hotspot to study how C．thermocellum senses the insoluble substrate，regulates the secretion of relevant enzymes，and assembles the supramolecular-degradation enzyme complex．This review summarized the research advance in genomics，transcriptomics，proteomics and extracellular carbohydrate-sensing mechanism in C．thermocellum，and analyzed the mechanism and dynamic process of C．thermocellum in lignocellulose degradation．