Actinomycetes from mangrove and their secondary metabolites

Abstract:

Abstract:Mangroves are woody plants located in tropical and subtropical intertidal coastal regions． Driven by the discovery of novel natural products from marine environment，mangrove is becoming a hot spot for actinomycetes resources collection and secondary metabolites (natural products) identification as well as their biosynthesis mechanism investigation．Salinaspora A produced by a Salinispora strain isolated from Bahamas mangrove environment，is in the first clinical trial．Till the time of writing this paper，24 genera of 11 families and 8 suborders under the actinomycetale have been reported from mangrove，among which 3 are new genera，and 31 are new species．At the same time，secondary metabolites were identified from the mangrove actinomycetes culture，including alkanoids and quinines，azalomycins，antimycins，bezamides and quinazolines，divergolides，indole derivatives，kandenols，macrocyclic dilactones，and the attractive structures，such as the Streptocarbazoles，the multicyclic indolsesquiterpenes，and xiamycin presented unique structures．Their biosynthetic mechanism has also been investigated． Most of the metabolites were isolated from streptomycetes，with a few from Micromonospora and Saccharopolyspora．