microRNA regulation on host-microbiota interaction—A review

Abstract:

Abstract:The intestinal environment is dependent on the host-microbiota interaction．Antigens of gut microbiota could affect the intestinal immunological homeostasis．Gut microbiota also participate in the metabolism of carbohydrate，lipid and protein． In return，the metabolites from these metabolic processes could regulate the bacterial metabolism，community composition and intestinal nutrient assimilation． MicroRNA serves as an important intracellular factor that regulates host gene expression．Gut microbiota could affect the host mRNA transcription and the post-transcription modification of certain genes by microRNA．Recent researches have revealed that gut microbiota could change the expression of microRNAs involved in gut inflammation and mucosal barrier via host-microbiota interaction．In this paper，we summarized recent advances in host-microbiota interaction and highlighted the research about microRNA regulation on gut homeostasis and host-microbiota interaction．