Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity

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Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity
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Fund Project:Supported by National Natural Science Foundation of China (81100326)，by the China Postdoctoral Science Foundation (2012M520684)，by the Basic Research Project of Jilin University (450060445322)，by the Jilin University Personnel Development Fund (4305050102Q5)，by the Foundation of Jilin Province Technological Committee (20090737) and by the Jilin Province Postdoctoral Science Foundation (801130020428)

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Abstract:

Abstract:［Objective］The ClfA adhesin of Staphylococcus aureus is an excellent vaccine candidate antigen． CD4 + T cells play central roles during immune responses，but their functional contributions to Staphylococcus aureus in fection have yet to be evaluated．［Methods］By using the SYFPEITHI prediction algorithm，we identified and characterized four Th epitopes within the ClfA adhesin.［Results］Peptide C335 was I-Ed restricted Th1 type epitopes; peptides C214，C286，and C436 were I-Ad restricted Th2 type epitope.［Conclusion］ The identification of these epitopes is important to evaluate and optimize the vaccine-primed protection against Staphylococcus aureus infection.

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Yang Li, Zhijie Li, Yagang Li, Junfeng Ye. Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity. [J]. Acta Microbiologica Sinica, 2013, 53(9): 966-975

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Received:March 28,2013
Revised:May 16,2013
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Online: August 29,2013
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