Systematic analysis and metabolic regulation of physiological functions for lactic acid bacteria—A review

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Systematic analysis and metabolic regulation of physiological functions for lactic acid bacteria—A review
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Fund Project:Supported by the Key Program of National Natural Science Foundation of China (20836003)，by the Major Project of China National Programs for Fundamental Research and Development (2007CB714303) and by the Priority Academic Program Development of Jiangsu Higher Education Institutions

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Abstract:

Abstract:As cell factories，lactic acid bacteria are widely used in food，agriculture，medicine and other industries，and play a great role in industrial processes． However，lactic acid bacteria encounter various environmental stresses both in industrial processes and in the gastrointestinal tract，which impair their physiological functions and food manufacture efficiency． Recently，the development of metabolic engineering and system biology brings unprecedented opportunity for the physiological modification of lactic acid bacteria． In this review，we addresses the progress of lactic acid bacterium system biology，and based on this，the metabolic engineering strategies for manipulating and optimizing lactic acid bacteria physiological function were summarized．

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Chongde Wu, Juan Zhang, Liming Liu. Systematic analysis and metabolic regulation of physiological functions for lactic acid bacteria—A review. [J]. Acta Microbiologica Sinica, 2012, 52(1): 22-29

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Received:June 07,2011
Revised:September 25,2011
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Online: January 13,2012
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