Advances in clustered regularly interspaced short palindromic repeats—A review

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Advances in clustered regularly interspaced short palindromic repeats—A review
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Fund Project:Supported by the National Natural Science Foundation of China ( 30930004)

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Abstract: The recently discovered Clustered Regularly Interspaced Short Palindromic Repeat (CRISPRs) can protect bacteria and archaea with adaptive and heritable defense systems against the invasion of phage- and plasmid- associated mobile genetic elements． Here，we review the structure，diversity，mechanism of interference and self versus non-self discrimination of CRISPR systems． We also discuss the potential applications of this novel interference system．

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Lili Wang, Jin He, Jieping Wang. Advances in clustered regularly interspaced short palindromic repeats—A review. [J]. Acta Microbiologica Sinica, 2011, 51(8): 1007-1013

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Received:January 19,2011
Revised:March 04,2011
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