Research progress in regulation of picornavirus infections by host kinases

Abstract:

Kinases are the major category of proteins that regulate intracellular signal transduction by phosphorylating target proteins. They catalyze the transfer of phosphate groups of high-energy donor molecules to specific substrates, serving as the key regulators of cell functions. Host kinases constitute a large protein family with diverse functions, guiding the activation, subcellular localization, and conformational changes of target proteins. In recent years, more and more studies have shown that host kinases play a regulatory role in the processes of picornavirus infections. Picornaviruses can cause a variety of diseases in human and animals. They lead to serious public health problems and huge economic burden in a global scope. A comprehensive understanding of the infection processes of picornaviruses is helpful for the prevention and treatment of these diseases. This paper reviews the research progress in the regulation of picornavirus infections by host kinases, aiming to comprehensively elucidate the mechanisms for interactions between host kinases and picornaviruses. At the same time, we discuss the potential of host kinases as effective treatments and drug targets against picornaviruses infection, aiming to provide implications for the development of new anti-picornavirus agents and vaccines in the future.