“同一健康”时代噬菌体的应用研究进展

Research progress of phage application in the era of One Health

摘要:

“同一健康”是环境、动物和人类三者健康的统合，涉及食品安全与环境卫生、动物与人类健康等诸多方面。目前，全球范围内耐药问题日益凸显，严重阻碍了“同一健康”目标的实现。噬菌体作为一种已有百年应用历史且能够特异性杀灭细菌的病毒，为解决耐药菌感染问题带来了新的希望。本文综述了噬菌体研究的发展历程、多样性及其在食品安全、环境、动物和人类健康中的应用，为“同一健康”时代噬菌体的应用提供了参考。

Abstract:

One Health integrates the health of the environment, animals, and humans, involving food safety, environmental hygiene, and animal and human health. Currently, antibiotic resistance is exacerbating worldwide, seriously hindering the achievement of One Health. Phages, as viruses with a century-long application history and the ability to specifically kill bacteria, bring new hope for addressing antibiotic-resistant bacterial infections. This article reviews the development history, diversity, and applications of phages in food safety and the environment, animals, and humans, with the aim of providing references for the application of phages in the era of One Health.