宿主激酶调控小RNA病毒感染的研究进展

Research progress in regulation of picornavirus infections by host kinases

摘要:

激酶是一种通过磷酸化作用调控细胞内信号传导的蛋白质，可催化高能供体分子的磷酸基团转移至特定底物上，是细胞功能的关键调节分子。激酶的功能多样，能够调控底物蛋白质的活化、亚细胞定位及构象改变。近年来，越来越多的研究表明，宿主激酶在小RNA病毒感染过程中发挥着重要的调控作用。小RNA病毒科成员可引起人和动物的多种疾病，曾在全球范围内引发严重的公共卫生问题，并造成巨大的经济负担。全面了解小RNA病毒的感染过程有助于预防和治疗这些疾病。本文综述了宿主激酶调控小RNA病毒感染的研究进展，旨在更全面地阐述宿主激酶与小RNA病毒的相互作用机制，同时讨论了宿主激酶作为预防疾病的有效措施及其药物靶点的可操作性，以期为未来开发新的抗小RNA病毒药物和疫苗研发提供启示。

Abstract:

Kinases are the major category of proteins that regulate intracellular signal transduction by phosphorylating target proteins. They catalyze the transfer of phosphate groups of high-energy donor molecules to specific substrates, serving as the key regulators of cell functions. Host kinases constitute a large protein family with diverse functions, guiding the activation, subcellular localization, and conformational changes of target proteins. In recent years, more and more studies have shown that host kinases play a regulatory role in the processes of picornavirus infections. Picornaviruses can cause a variety of diseases in human and animals. They lead to serious public health problems and huge economic burden in a global scope. A comprehensive understanding of the infection processes of picornaviruses is helpful for the prevention and treatment of these diseases. This paper reviews the research progress in the regulation of picornavirus infections by host kinases, aiming to comprehensively elucidate the mechanisms for interactions between host kinases and picornaviruses. At the same time, we discuss the potential of host kinases as effective treatments and drug targets against picornaviruses infection, aiming to provide implications for the development of new anti-picornavirus agents and vaccines in the future.