中药协同抗真菌药物抗隐球菌的研究进展

Research progress in combined application of traditional Chinese medicines and antifungal agents in treating Cryptococcus infections

摘要:

隐球菌是一种全球分布的侵袭性真菌，已经引起了严重的公共卫生问题。隐球菌致病菌种主要以新型隐球菌为代表，其在感染人体后可引起死亡率极高的肺隐球菌病及隐球菌脑膜炎等。目前传统抗真菌药物只有多烯类、氟胞嘧啶类、棘白菌素类和唑类四类，在临床中单独用药时存在治疗效果不显著以及导致耐药等情况出现。因此，研究人员把视角转向联合用药，并发现一些中药及天然植物提取物和衍生物与传统抗真菌药物联合使用对治疗隐球菌病具有良好的协同效果，本文就中药联合抗真菌药物研究现状进行总结。

Abstract:

Cryptococcus, a genus of invasive fungi with global distribution, have caused serious public health problems. Notably, Cryptococcus neoformans (Cryptococcus neoformans, C. neoformans) represents the main pathogenic species of Cryptococcus. The infection of C. neoformans can cause pulmonary cryptococcosis and cryptococcal meningitis with high mortality rates. The commonly used antifungal drugs are polyenes, flucytosine, echinocandins, and azoles, which have limited efficacy and may induce resistance when being used alone in clinical practice. Therefore, researchers have studied combined therapy. They have discovered that the combinations of some traditional Chinese medicines and natural plant extracts and derivatives with the commonly used antifungal drugs demonstrate synergistic effects in the treatment of cryptococcosis. This paper reviews the research progress in the combined application of antifungal drugs and traditional Chinese medicines.