丝状真菌衰老的研究进展

Research progress in senescence of filamentous fungi

摘要:

丝状真菌的衰老是一个涉及多种生理生化变化的复杂过程，受外部环境和遗传的共同影响，且伴随细胞功能退化与生理损伤。丝状真菌因其遗传操作容易、生命周期短、便于量化的衰老特征等优势被广泛用于衰老机制研究。本研究对丝状真菌的衰老特征进行综述，并归纳环境因素、线粒体稳定性、氧化应激和代谢水平等影响衰老的因素，解析衰老过程的调控机制，进一步挖掘丝状真菌在工业应用中的应用价值，期望能为人类衰老的研究提供新的研究思路。

Abstract:

Senescence, a complex process involving multiple physiological and biochemical processes accompanied by degradation of cellular and organ functions and physiological damage, is influenced by both environmental and genetic factors. Filamentous fungi have been widely used in the study of senescence mechanism because of the easy genetic manipulation, short life cycle, and easy qualification of senescence characteristics. In this paper, we reviewed the senescence characteristics of filamentous fungi and summarized the factors influencing aging, such as environmental factors, mitochondrial stability, oxidative stress, and metabolic level. This review is expected to give new insights into the industrial application of filamentous fungi and the research on human senescence.